Q I started two new medications a few months ago, and suddenly my cholesterol is too high. It’s so bizarre because I had perfect numbers all my life, and I eat well and exercise. Can drugs raise cholesterol? – J.G., Breckenridge, Colo.

A Yes, hundreds of them can. Something you take every day for one condition can cause your cholesterol to creep up. People are always shocked when they find out they are causing their cholesterol problems (either with low-carb diets, or with medications). Some dietary supplements can raise it too. If you think your medication is causing high cholesterol, speak with your doctor about discontinuing it, or switching meds. Some that cause hypercholesterolemia include:

Rosiglitazone (Avandia).

This diabetes drug can raise cholesterol. And that’s the least of its worries, as there also have been consistent reports of life-threatening reactions.

Vitamin D.

I love this antioxidant, but some people are overdoing it. Excessive D can cause excessive calcium in the blood, and this can cause hypercholesterolemia.

Diuretics.

These “water pills” help reduce blood pressure. The “thiazide” and “loop” diuretics are known to elevate total cholesterol, LDL and blood glucose. Hydrochlorothiazide (HCTZ) is sold as a drug itself, and also found in dozens of combo drugs under various brand names, usually ending in “HCT.” And furosemide (brand name Lasix) may be the world’s most popular loop diuretic. Any med that contains HCTZ or furosemide may contribute to high cholesterol.

Escitalopram (Lexapro).

This popular antidepressant is related to Celexa. The slight elevation was shown in post-marketing studies.

Fluoxetine (Prozac).

Another popular antidepressant, this may raise cholesterol, cause hypoglycemia and trigger gout episodes. It may reduce iron and potassium (sparking cardiac arrhythmias).

Creatine.

In large doses, this dietary supplement may cause a slight elevation in cholesterol.

Prednisone.

This anti-inflammatory drug and its cousins in the “corticosteroid” class can cause high cholesterol with chronic use.

Olanzapine (Zyprexa).

Used to treat schizophrenia, it has caused severe elevations in triglycerides (greater than 500 mg/dL) in some individuals.

This information is not intended to treat, cure or diagnose your condition. Go to SuzyCohen.com.